The Big Bang Theory
Created by writer/producers Chuck Lorre (of Two and a Half Men) and Bill Prady (of Gilmore Girls) comes The Big Bang Theory , a sitcom that shows what happens when hyperintelligent roommates/physicists Sheldon Cooper (Jim Parsons) and Leonard Hofstadter (Johnny Galecki) meet Penny (Kaley Cuoco), a beautiful woman moving in next door, and realize they know next to nothing about life outside of the lab. Rounding out the crew are the smarmy Howard Wolowitz (Simon Helberg), who thinks he's as sexy as he is brainy, and Rajesh Koothrappali (Kunal Nayyar), who suffers from an inability to speak in the presence of a woman. The show distinguishes itself by being unafraid to toss scientific references and technobabble into an otherwise standard sitcom, even employing a physicist to keep things accurate. In doing so, it allows Sheldon and Leonard to do for science what Frasier's Crane brothers did for fine dining, art and opera.
More information: IMDB